2. Signaling Pathways
  3. Membrane Transporter/Ion Channel
  4. Sodium Channel

Sodium Channel

Na channels; Na+ channels

Sodium Channel

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Sodium channels are integral membrane proteins that form ion channels, conducting sodium ions (Na+) through a cell's plasma membrane. They are classified according to the trigger that opens the channel for such ions, i.e. either a voltage-change (Voltage-gated, voltage-sensitive, or voltage-dependent sodium channel also called VGSCs or Nav channel) or a binding of a substance (a ligand) to the channel (ligand-gated sodium channels). In excitable cells such as neurons, myocytes, and certain types of glia, sodium channels are responsible for the rising phase of action potentials. Voltage-gated Na+ channels can exist in any of three distinct states: deactivated (closed), activated (open), or inactivated (closed). Ligand-gated sodium channels are activated by binding of a ligand instead of a change in membrane potential.

Sodium Channel Isoform Specific Products:

Sodium Channel Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-W027553R
    Ipidacrine (Standard)
    		Inhibitor
    Ipidacrine is orally active and brain-penetrant AChE and BuChE inhibitors with IC50 values of 1 μM and 1.9 μM, respectively, which is also a partial agonist of M2-cholinergic receptors and a reversible cholinesterase inhibitor. Ipidacrine has a stimulating effect on neuromuscular transmission and excitation along the nerve fibres with a moderately anti-pain effect. Ipidacrine is an aminopyridines and is structurally similar to Tacrine (HY-111338). Ipidacrine is effective in various amnesia models, improves erectile function and inhibits K+ and Na+-channels in the neuronal membrane in diabetic rats. Ipidacrine is promising for research of Alzheimer’s disease, ischaemic stroke, idiopathic neuropathy of the facial nerve, diabetes mellitus-induced erectile dysfunction and other deficits in central or peripheral cholinergic deseases.
    Ipidacrine (Standard)
  • HY-124232
    BTG 502
    BTG 502 is an alkylamide insecticide. BTG 502 can reduce sodium current and antagonize the effect of bat toxin (BTX) on cockroach sodium channels.
    BTG 502
  • HY-17401R
    Ranolazine dihydrochloride (Standard)
    		Inhibitor
    Ranolazine (dihydrochloride) (Standard) is the analytical standard of Ranolazine (dihydrochloride). This product is intended for research and analytical applications. Ranolazine dihydrochloride (CVT 303 dihydrochloride) is an anti-angina agent that achieves its effects by inhibiting the late phase of inward sodium current (INa and IKr with IC50 values of 6 μM and 12 μM, respectively) without affecting heart rate or blood pressure (BP). Ranolazine dihydrochloride is also a partial fatty acid oxidation inhibitor.
    Ranolazine dihydrochloride (Standard)
  • HY-106616R
    Muzolimine (Standard)
    		Agonist
    Muzolimine (Standard) is the analytical standard of Muzolimine. This product is intended for research and analytical applications. Muzolimine (BAY-g 282) is a slow and long lasting diuresis agent. Muzolimine produces a diuresis in the loop of Henle and also shows anti-hypertensive and natriuresis effects. Muzolimine can be used for the research of cardiovascular disease.
    Muzolimine (Standard)
  • HY-B0185S
    N-Oxide Lidocaine-d10
    		Inhibitor
    N-Oxide Lidocaine-d10 is the deuterium labeled Lidocaine. Lidocaine (Lignocaine) inhibits sodium channels involving complex voltage and using dependence. Lidocaine decreases growth, migration and invasion of gastric carcinoma cells via up-regulating miR-145 expression and further inactivation of MEK/ERK and NF-κB signaling pathways. Lidocaine is an amide derivative and has potential for the research of ventricular arrhythmia.
    N-Oxide Lidocaine-d<sub>10</sub>
  • HY-B1280R
    Nikethamide (Standard)
    Nikethamide (Standard) is the analytical standard of Nikethamide. This product is intended for research and analytical applications. Nikethamide, one of the respiratory central stimulants, has the potential for respiratory failure research.
    Nikethamide (Standard)
  • HY-B0122S1
    Topiramate-13C
    		Inhibitor
    Topiramate-13C (McN 4853-13C) is 13C labeled Topiramate. Topiramate (McN 4853) is a broad-spectrum antiepileptic agent. Topiramate is a GluR5 receptor antagonist. Topiramate produces its antiepileptic effects through enhancement of GABAergic activity, inhibition of kainate/AMPA receptors, inhibition of voltage-sensitive sodium and calcium channels, increases in potassium conductance, and inhibition of carbonic anhydrase.
    Topiramate-<sup>13</sup>C<sub>
  • HY-172005
    10,11-Dihydroxycarbamazepine
    10,11-Dihydroxycarbamazepine is a metabolite of the anticonvulsant Carbamazepine (HY-B0246). Carbamazepine is an orally active pressure-sensitive sodium ion channel blocker.
    10,11-Dihydroxycarbamazepine
  • HY-B1288R
    Oxybuprocaine hydrochloride (Standard)
    		Inhibitor
    Oxybuprocaine (hydrochloride) (Standard) is the analytical standard of Oxybuprocaine (hydrochloride). This product is intended for research and analytical applications. Oxybuprocaine hydrochloride (Benoxinate hydrochloride) reversibly blocks sodium channels and prevents propagation of painful nerve impulses in the cornea, conjunctiva, and sclera. Oxybuprocaine hydrochloride is used especially in ophthalmology and otolaryngology.
    Oxybuprocaine hydrochloride (Standard)
  • HY-W803860
    N-Depropylpropafenone
    		Antagonist
    N-Depropylpropafenone is an active metabolite of Propafenone (HY-B0432), generated through the CYP450 enzyme system (mainly CYP2D6). It functions by blocking sodium ion channels, slowing myocardial conduction and exhibiting certain antiarrhythmic effects.
    N-Depropylpropafenone
  • HY-B0448R
    Phenytoin (Standard)
    		Inhibitor
    Phenytoin (Standard) is the analytical standard of Phenytoin. This product is intended for research and analytical applications. Phenytoin (5,5-Diphenylhydantoin) is a potent Voltage-gated Na+ channels (VGSCs) blocker. Phenytoin has antiepileptic activity and reduces breast tumour growth and metastasis in mice.
    Phenytoin (Standard)
  • HY-107186
    EO-122
    		Antagonist
    EO-122 is a potent antagonist of calcium channel and sodium channel potentially for the research of arrhythmia.
    EO-122
  • HY-B1319R
    Pramocaine hydrochloride (Standard)
    		Inhibitor
    Pramocaine (hydrochloride) (Standard) is the analytical standard of Pramocaine (hydrochloride). This product is intended for research and analytical applications. Pramocaine hydrochloride decreases the permeability of neuronal membranes to sodium ions, blocking both initiation and conduction of nerve impulses.
    Pramocaine hydrochloride (Standard)
  • HY-107405S
    TC-N 1752-d5
    		Inhibitor
    TC-N 1752-d5 is deuterium-labeled TC-N 1752 (HY-107405).
    TC-N 1752-d<sub>5</sub>
  • HY-108506S4
    Licarbazepine-d8
    		Inhibitor
    Licarbazepine-d8 (BIA 2-005-d8) is deuterium labeled Licarbazepine. Licarbazepine (BIA 2-005; GP 47779)?is a?voltage-gated sodium channel?blocker?with?anticonvulsant?and?mood-stabilizing?effects.
    Licarbazepine-d8
  • HY-135478A
    LY393615 free base
    		Inhibitor
    LY393615 (NCC1048) free base is a novel neuronal Ca2+ (calcium channel) and Na + channel (sodium channel) blocker with IC50s of 1.9 μΜ and 5.2 μΜ for α1A and α1B calcium channel subunits. LY393615 free base has good brain penetration and neuroprotective effects in models of in cerebral ischemia that can be used for neurological disease research.
    LY393615 free base
  • HY-B0358AR
    Flunarizine dihydrochloride (Standard)
    		Inhibitor
    Flunarizine (dihydrochloride) (Standard) is the analytical standard of Flunarizine (dihydrochloride). This product is intended for research and analytical applications. Flunarizine dihydrochloride is a potent dual Na+/Ca2+ channel (T-type) blocker. Flunarizine dihydrochloride is a D2 dopamine receptor antagonist. Flunarizine dihydrochloride shows anticonvulsive and antimigraine activity, and peripheral vasodilator effects.
    Flunarizine dihydrochloride (Standard)
  • HY-B0358R
    Flunarizine (Standard)
    		Inhibitor
    Flunarizine (Standard) is the analytical standard of Flunarizine. This product is intended for research and analytical applications. Flunarizine is a potent dual Na+/Ca2+ channel (T-type) blocker. Flunarizine is a D2 dopamine receptor antagonist. Flunarizine shows anticonvulsive and antimigraine activity, and peripheral vasodilator effects.
    Flunarizine (Standard)
  • HY-126645
    Atelopidtoxin
    		Inhibitor
    Atelopidtoxin (zetekitoxin) is a toxin (LD50=0.016 mg/kg for mice), which can be isolated from Panamanian frog Atelopus zeteki. Atelopidtoxin causes hypotension and ventricular fibrillation in rabbits. Atelopidtoxin an inhibitor for sodium channel.
    Atelopidtoxin
  • HY-137172
    ETH 157
    ETH 157 is a Na+ ionophore that induces a Na+/Ca2+ selectivity in membranes.
    ETH 157
Cat. No. Product Name / Synonyms Application Reactivity
Sodium Channel Isoform Comparison

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